
Ombrabulin hydrochloride
CAS No. 253426-24-3
Ombrabulin hydrochloride ( AVE-8062 | AVE-8062A | AC-7700 )
产品货号. M13754 CAS No. 253426-24-3
一种新型考布他汀 A-4 衍生物,可强烈抑制肿瘤血流并抑制各种组织和器官中肿瘤的生长。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
10MG | ¥5292 | 有现货 |
![]() ![]() |
50MG | ¥15876 | 有现货 |
![]() ![]() |
100MG | 获取报价 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称Ombrabulin hydrochloride
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述一种新型考布他汀 A-4 衍生物,可强烈抑制肿瘤血流并抑制各种组织和器官中肿瘤的生长。
-
产品描述A novel combretastatin A-4 derivative that strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organ; a vascular-disrupting agent.Ovarian Cancer Phase 2 Clinical.
-
体外实验The effect of Ombrabulin (AVE8062) on endothelial or tumor cell viability is examined using the MTT assay. The IC50 of Ombrabulin for the mouse mesenteric endothelial cells (MMEC) is 10 nM and ranges between 7 and 20 nM for the tumor cell lines (HeyA8, SKOV3ip1, and HeyA8-MDR). Comparative analysis of the nonlinear least-squares regression of the dose-response curves for each agent alone and combination Ombrabulin /Docetaxel show a significantly lower IC50 than either agent alone (P<0.005, all cell lines). The cytotoxicity of Docetaxel is 2- to 4-fold greater in combination with Ombrabulin for the endothelial and tumor cells compared with Docetaxel alone.
-
体内实验Before performing therapy experiments, the tolerability of various doses of Ombrabulin (AVE8062) ranging from 10 to 100 mg/kg is tested given twice weekly via i.v., i.p., or s.c. routes in nude mice (n=3 per group). The i.v. and s.c. routes are not pursued further due to problems with skin or tail vein necrosis. The i.p. route is well tolerated with doses up to 100 mg/kg. Next, preliminary experiments are done to determine the lowest dose for in vivo therapeutic efficacy. Starting 7 days after tumor cell injection, nude mice (n=5 per group) bearing HeyA8 ovarian cancer cells are treated with either vehicle or Ombrabulin 10, 30, 50, and 100 mg/kg twice weekly i.p. for 3 weeks. There is 65% reduction in tumor weight in the 30 mg/kg group compared with the vehicle control group (P<0.02). The 10 mg/kg dose is not effective. The antitumor effects at doses >30 mg/kg are not significantly better; therefore, the 30 mg/kg dose is selected for subsequent therapy experiments.
-
同义词AVE-8062 | AVE-8062A | AC-7700
-
通路Others
-
靶点Other Targets
-
受体Other Targets
-
研究领域Cancer
-
适应症Ovarian Cancer
化学信息
-
CAS Number253426-24-3
-
分子量438.9019
-
分子式C21H27ClN2O6
-
纯度>98% (HPLC)
-
溶解度10 mM in DMSO; Methanol: ≥ 30 mg/mL
-
SMILESO=C(NC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC)[C@@H](N)CO.[H]Cl
-
化学全称Propanamide, 2-amino-3-hydroxy-N-[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]-, hydrochloride (1:1), (2S)-
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Hori K, et al. Br J Cancer. 2002 May 20;86(10):1604-14.
2. Kim TJ, et al. Cancer Res. 2007 Oct 1;67(19):9337-45.
3. Sessa C, et al. Clin Cancer Res. 2013 Sep 1;19(17):4832-42.
产品手册




关联产品
-
Glucosyringic acid
葡萄糖丁酸具有免疫抑制作用,在体外能抑制小鼠B淋巴细胞的增殖。
-
Tertiapin LQ
Blocker of Kir1.1 channels; displays >250-fold selectivity for Kir1.1 (Kd values are 1.1, 274 and 361 nM for Kir1.1, Kir3.1/3.2 and Kir3.1/3.4 respectively). Derivative of tertiapin-Q.
-
4,5-Di-O-caffeoylqui...
4,5-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV.